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1

New Antibiotics from Nature’s Chemical Inventory

Wencewicz, Timothy A.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 8.79 MB

english, 2016

2

Antibiotics (Challenges, Mechanisms, Opportunities) || Mechanisms: Bacterial Resistance to Antibiotics

Walsh, Christopher, Wencewicz, Timothy

Year:

2016

File:

PDF, 30 KB

2016

3

ChemInform Abstract: Syntheses and Antibacterial Activity Studies of New Oxazolidinones from Nitroso Diels—Alder Chemistry.

Shanshan Yan, Marvin J. Miller, Timothy A. Wencewicz, Ute Moellmann

Journal:

Year:

2010

File:

PDF, 23 KB

2010

4

Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic conjugates

Timothy A. Wencewicz, Ute Möllmann, Timothy E. Long, Marvin J. Miller

Journal:

Year:

2009

Language:

english

File:

PDF, 745 KB

english, 2009

5

Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels–Alder chemistry

Shanshan Yan, Marvin J. Miller, Timothy A. Wencewicz, Ute Möllmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 295 KB

english, 2010

6

Iron(III)-Templated Macrolactonization of Trihydroxamate Siderophores

Wencewicz, Timothy A., Oliver, Allen G., Miller, Marvin J.

Journal:

Organic Letters

Year:

2012

Language:

english

File:

PDF, 949 KB

english, 2012

7

Trihydroxamate Siderophore–Fluoroquinolone Conjugates Are Selective Sideromycin Antibiotics that Target Staphylococcus aureus

Wencewicz, Timothy A., Long, Timothy E., Möllmann, Ute, Miller, Marvin J.

Journal:

Bioconjugate Chemistry

Year:

2013

Language:

english

File:

PDF, 3.61 MB

english, 2013

8

Biscatecholate–Monohydroxamate Mixed Ligand Siderophore–Carbacephalosporin Conjugates are Selective Sideromycin Antibiotics that Target Acinetobacter baumannii

Wencewicz, Timothy A., Miller, Marvin J.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.01 MB

english, 2013

9

N–O Chemistry for Antibiotics: Discovery of N -Alkyl- N -(pyridin-2-yl)hydroxylamine Scaffolds as Selective Antibacterial Agents Using Nitroso Diels–Alder and Ene Chemistry

Wencewicz, Timothy A., Yang, Baiyuan, Rudloff, James R., Oliver, Allen G., Miller, Marvin J.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.23 MB

english, 2011

10

Prospects for new antibiotics: a molecule-centered perspective

Walsh, Christopher T, Wencewicz, Timothy A

Journal:

The Journal of Antibiotics

Year:

2014

Language:

english

File:

PDF, 4.29 MB

english, 2014

11

Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates

Yan, Shanshan, Miller, Marvin J., Wencewicz, Timothy A., Möllmann, Ute

Journal:

Year:

2010

Language:

english

File:

PDF, 127 KB

english, 2010

12

Pseudomonas syringae Self-Protection from Tabtoxinine-β-Lactam by Ligase TblF and Acetylase Ttr

Wencewicz, Timothy A., Walsh, Christopher T.

Journal:

Year:

2012

Language:

english

File:

PDF, 679 KB

english, 2012

13

The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes

Forsberg, Kevin J., Patel, Sanket, Wencewicz, Timothy A., Dantas, Gautam

Journal:

Chemistry & Biology

Year:

2015

Language:

english

File:

PDF, 2.72 MB

english, 2015

14

Tabtoxinine-β-lactam is a “stealth” β-lactam antibiotic that evades β-lactamase-mediated antibiotic resistance

Hart, Kathryn M., Reck, Margaret, Bowman, Gregory R., Wencewicz, Timothy A.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.66 MB

english, 2015

15

Ceric Ammonium Nitrate Catalyzed Oxidation of Sulfides to Sulfoxides

Ali, Mohammed, Kriedelbaugh, Donna, Wencewicz, Timothy

Journal:

Year:

2007

Language:

english

File:

PDF, 94 KB

english, 2007

16

Acinetobactin Isomerization Enables Adaptive Iron Acquisition in Acinetobacter baumannii through pH-Triggered Siderophore Swapping

Shapiro, Justin A., Wencewicz, Timothy A.

Journal:

ACS Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 2.47 MB

english, 2015

17

Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells

Gelman, Susan J., Mahieu, Nathaniel G., Cho, Kevin, Llufrio, Elizabeth M., Wencewicz, Timothy A., Patti, Gary J.

Journal:

Cancer & Metabolism

Year:

2015

Language:

english

File:

PDF, 1.26 MB

english, 2015

18

Structure–function studies of acinetobactin analogs

Shapiro, Justin A., Wencewicz, Timothy A.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.04 MB

english, 2017

19

Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes

Park, Jooyoung, Gasparrini, Andrew J, Reck, Margaret R, Symister, Chanez T, Elliott, Jennifer L, Vogel, Joseph P, Wencewicz, Timothy A, Dantas, Gautam, Tolia, Niraj H

Journal:

Nature Chemical Biology

Year:

2017

Language:

english

File:

PDF, 2.92 MB

english, 2017

20

β-Lactone formation during product release from a nonribosomal peptide synthetase

Schaffer, Jason E, Reck, Margaret R, Prasad, Neha K, Wencewicz, Timothy A

Journal:

Nature Chemical Biology

Year:

2017

Language:

english

File:

PDF, 1.57 MB

english, 2017

21

[Topics in Medicinal Chemistry] || Sideromycins as Pathogen-Targeted Antibiotics

Wencewicz, Timothy A.

Year:

2017

Language:

english

File:

PDF, 811 KB

english, 2017

22

Structural Basis for Xenosiderophore Utilization by the Human Pathogen Staphylococcus aureus

Endicott, Nathaniel P., Lee, Eries, Wencewicz, Timothy Adam

Journal:

ACS Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 1.39 MB

english, 2017

23

Rigid Oxazole Acinetobactin Analog Blocks Siderophore Cycling in Acinetobacter baumannii

Bohac, Tabbetha J., Shapiro, Justin A., Wencewicz, Timothy A.

Journal:

ACS Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

24

Mechanistic Basis for ATP-Dependent Inhibition of Glutamine Synthetase by Tabtoxinine-β-Lactam

Patrick, Garrett, Fang, Luting, Schaefer, Jacob, Singh, Sukrit, Bowman, Gregory, Wencewicz, Timothy Adam

Journal:

Year:

2017

Language:

english

File:

PDF, 1.37 MB

english, 2017

25

Immobilized FhuD2 Siderophore-Binding Protein Enables Purification of Salmycin Sideromycins from Streptomyces violaceus DSM 8286

Rivera, Gerry Sann M., Beamish, Catherine Rose, Wencewicz, Timothy Adam

Journal:

ACS Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 1.45 MB

english, 2018

26

Stream-lined synthesis of 3-hydroxy-β-Lactams: Norrish-Yang type II photocyclizations of β-ketoformamides

Markley, Jana L., Morse, Tyler L., Rath, Nigam P., Wencewicz, Timothy A.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.33 MB

english, 2018

27

Tetracycline-Inactivating Enzymes

Markley, Jana L., Wencewicz, Timothy A.

Journal:

Frontiers in Microbiology

Year:

2018

Language:

english

File:

PDF, 9.37 MB

english, 2018

28

Crystal Structure of the Siderophore Binding Protein BauB Bound to an Unusual 2:1 Complex Between Acinetobactin and Ferric Iron

Bailey, Daniel C., Bohac, Tabbetha J, Shapiro, Justin A, Giblin, Daryl E., Wencewicz, Timothy Adam, Gulick, Andrew M.

Journal:

Year:

2018

Language:

english

File:

PDF, 2.54 MB

english, 2018

29

Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes

Markley, Jana L., Fang, Luting, Gasparrini, Andrew J., Symister, Chanez T., Kumar, Hirdesh, Tolia, Niraj H., Dantas, Gautam, Wencewicz, Timothy A.

Journal:

ACS Infectious Diseases

Year:

2019

File:

PDF, 11.57 MB

2019

30

Crossroads of Antibiotic Resistance and Biosynthesis

Wencewicz, Timothy A.

Journal:

Journal of Molecular Biology

Year:

2019

Language:

english

File:

PDF, 4.97 MB

english, 2019

31

The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase

Kreitler, Dale F., Gemmell, Erin M., Schaffer, Jason E., Wencewicz, Timothy A., Gulick, Andrew M.

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 2.17 MB

english, 2019

32

Emergence of Ferrichelatase Activity in a Siderophore-Binding Protein Supports an Iron Shuttle in Bacteria

Endicott, Nathaniel P., Rivera, Gerry Sann M., Yang, Jinping, Wencewicz, Timothy A.

Journal:

ACS Central Science

Year:

2020

File:

PDF, 6.35 MB

2020

33

Antibiotics (Challenges, Mechanisms, Opportunities) || Front Matter

Walsh, Christopher, Wencewicz, Timothy

Year:

2016

File:

PDF, 243 KB

2016

34

Antibiotics (Challenges, Mechanisms, Opportunities) || Mechanisms: Antibiotic Action by Bacterial Target Class

Walsh, Christopher, Wencewicz, Timothy

Year:

2016

File:

PDF, 31 KB

2016

35

Antibiotics (Challenges, Mechanisms, Opportunities) || Mechanisms: Antibiotic Biosynthesis

Walsh, Christopher, Wencewicz, Timothy

Year:

2016

File:

PDF, 22 KB

2016

36

Antibiotics (Challenges, Mechanisms, Opportunities) || Challenges for Antibiotics

Walsh, Christopher, Wencewicz, Timothy

Year:

2016

File:

PDF, 28 KB

2016

37

Antibiotics (Challenges, Mechanisms, Opportunities) || Index

Walsh, Christopher, Wencewicz, Timothy

Year:

2016

File:

PDF, 107 KB

2016

38

Antibiotics (Challenges, Mechanisms, Opportunities) || References

Walsh, Christopher, Wencewicz, Timothy

Year:

2016

File:

PDF, 433 KB

2016